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Upon reduction, PMO changes color from colorless to blue, and the intensity of this blue color directly reflects the extent of the reduction (Zou et al., 2018

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In addition, acetaminophen exposure itself induces increased CYP2E1, thus increasing the amount of NAPQI formed with each exposure to the drug.Posadas et al

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These species can lead to free radical reactions in living organisms (Phaniendra et al., 2015)

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4.4 Unanswered questions and future research directions Despite significant strides in understanding the interplay between the gut microbiota, bile acid (BA) metabolism, and the TIME, critical questions remain, paving the way for future research

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